abstract：:The trypsin-assisted extraction of polysaccharides from Allium cepa L. was optimized using the response surface methodology (RSM). The optimum extraction conditions were extraction temperature, extraction time, extraction pH, and enzyme amount of 37.16°C, 180 min, 8.57, and 5.16%, respectively. Under the optimized con...

authors： Ji YB,Wang FL

更新日期：2021-12-01 00:00:00

abstract：:To develop unique small-molecule inhibitors of hepatitis C virus (HCV), thiophen urea (TU) derivatives were synthesised and screened for HCV entry inhibitory activities. Among them, seven TU compounds exhibited portent anti-viral activities against genotypes 1/2 (EC50 < 30 nM) and subsequently, they were further inves...

authors： Ryu HC,Windisch M,Lim JW,Choi I,Lee EK,Yoo HH,Kim TK

更新日期：2021-12-01 00:00:00

abstract：:Ursolic acid (UA), found widely in nature, exerts effective anti-tumoral activity against various malignant tumors. However, the low water solubility and poor bioavailability of UA have greatly hindered its translation to the clinic. To overcome these drawbacks, a simple redox-sensitive UA polymeric prodrug was synthe...

authors： Fu D,Ni Z,Wu K,Cheng P,Ji X,Li G,Shang X

更新日期：2021-12-01 00:00:00

abstract：:The association of neutrophil-to-lymphocyte ratio (NLR) and mean platelet volume (MPV) with the severe gastrointestinal (GI) involvement in pediatric Henoch-Schonlein Purpura (HSP) has been reported in many studies. However, the conclusions from the previous studies were controversial. Therefore, for the first time, w...

authors： Li B,Ren Q,Ling J,Tao Z,Yang X,Li Y

更新日期：2021-12-01 00:00:00

abstract：:Increasingly attention is being given to immune molecules in pancreatic cancer. The purpose of this study was to understand the potential clinical application of immune-regulated genes (IRGs) in the stratification of prognosis and to facilitate the development of personalized prognostic information for pancreatic canc...

authors： Li Y,Yao P,Zhao K,Ye Z,Zhang H,Cao J,Zhang S,Xing C

更新日期：2021-12-01 00:00:00

abstract：:Obesity is an important public-health problem worldwide. This study aimed to determine effects of porphyromonas gingivalis lipopolysaccharide (Pg-LPS) on adipocytes injuries and explore associated mechanisms. Adipocytes were isolated from SD rats. pLVX-XBP1 (XBP1 over-expression) and pLVX-XBP1-RNAi (silencing XBP1) we...

authors： Lv YT,Zeng JJ,Lu JY,Zhang XY,Xu PP,Su Y

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Hemophilia A (HA, OMIM: 306700) is an X-linked recessive bleeding disorder, caused by defects of the F8 gene which encodes the coagulation factor VIII (FVIII). F8 intron 22 and intron 1 inversion (Inv22 and Inv1) account for ∼45% and 1-5% of severe HA cases, respectively. We herein described an aberrant Inv1...

authors： Wang X,Wang H,Tan H,Liu XP,Li H

更新日期：2021-12-01 00:00:00

abstract：:Abnormalities in CD4+ T cell (Th cell) differentiation play an important role in the pathogenesis of viral myocarditis (VMC). Our previous studies demonstrated that activation of the cholinergic anti-inflammatory pathway (CAP) alleviated the inflammatory response. In addition, we observed that right cervical vagotomy ...

authors： Yue-Chun L,Gu XH,Li-Sha G,Zhou DP,Xing C,Guo XL,Pan LL,Song SY,Yu LL,Chen GY,Lin JF,Chu MP

更新日期：2021-12-01 00:00:00

abstract：:Macrophage differentiation is associated with tumorigenesis, including the tumorigenesis of hepatocellular carcinoma (HCC). Herein, we explored the value of macrophage differentiation-associated genes (MDGs) in the prognosis of HCC using data from The Cancer Genome Atlas (TCGA) and the International Cancer Genome Cons...

authors： Cao J,Zhang C,Jiang GQ,Jin SJ,Wang Q,Wang AQ,Bai DS

更新日期：2021-12-01 00:00:00

abstract：OBJECTIVES:Our aim is to evaluate initial efficacy, safety, and durable response of eltrombopag in the treatment of Chinese children with chronic immune thrombocytopenia (cITP). METHODS:This was a retrospective, single-center cohort study including 30 pediatric patients with cITP administered eltrombopag between 1 Jul...

authors： Chen M,Fang JP,Zhou CX,Li XY,Lin SF,Xu LH

更新日期：2021-12-01 00:00:00

abstract：:A set of quinazolinones synthesized by the aid of L-norephedrine was assembled to generate novel analogues as potential anticancer and radiosensitizing agents. The new compounds were evaluated for their cytotoxic activity against MDA-MB-231, MCF-7, HepG-2, HCT-116 cancer cell lines and EGFR inhibitory activity. The mo...

authors： Ghorab MM,Abdel-Kader MS,Alqahtani AS,Soliman AM

更新日期：2021-12-01 00:00:00

abstract：:HBV pol plays a critical role in the replication of hepatitis B virus (HBV). Previous studies conducted on HBV pol have produced limited evidence on HBV pol expression due to the lack of effective detection methods. The present study used the HBV pol (159-406 aa) protein as a target to screen for specific monoclonal a...

authors： Hu S,Xiong H,Kang X,Wang S,Zhang T,Yuan Q,Tian D

更新日期：2021-12-01 00:00:00

abstract：:Our understanding of adipose tissue has progressed from an inert tissue for energy storage to be one of the largest endocrine organs regulating metabolic homoeostasis through its ability to synthesize and release various adipokines that regulate a myriad of pathways. The field of adipose tissue biology is growing due ...

authors： Al-Sayegh M,Ali H,Jamal MH,ElGindi M,Chanyong T,Al-Awadi K,Abu-Farha M

更新日期：2021-12-01 00:00:00

abstract：:Control of hyperglycemia and prevention of glucose reabsorption (glucotoxicity) are important objectives in the management of type 2 diabetes. This study deals with an oral combined dosage form design for two anti-diabetic drugs, sitagliptin and dapagliflozin using self-nanoemulsifying drug delivery systems (SNEDDS). ...

authors： Kazi M,Alqahtani A,Ahmad A,Noman OM,Aldughaim MS,Alqahtani AS,Alanazi FK

更新日期：2021-12-01 00:00:00

abstract：:Small-molecules acting as positive allosteric modulators (PAMs) of the A2B adenosine receptor (A2B AR) could potentially represent a novel therapeutic strategy for pathological conditions characterised by altered bone homeostasis, including osteoporosis. We investigated a library of compounds (4-13) exhibiting differe...

authors： Barresi E,Giacomelli C,Marchetti L,Baglini E,Salerno S,Greco G,Da Settimo F,Martini C,Trincavelli ML,Taliani S

更新日期：2021-12-01 00:00:00

abstract：:Purpose: In order for health professionals to encourage pregnant women with a low socioeconomic status (SES) to move towards empowerment for a healthy dietary intake, crucial steps are to understand the perspectives of pregnant women of food and eating and to identify opportunities for empowerment. This study aimed to...

authors： Super S,Wagemakers A

更新日期：2021-12-01 00:00:00

abstract：:It is necessary to explore new molecules for the improvement of precise diagnosis and antitumor therapies in lung cancer. LncRNAs (long non-coding RNAs) play an important role in the regulation of cancer cell malignant behavior and tumor development. In this work, we found that a newly discovered lncRNA, lncRNA PGM5P4...

authors： Feng J,Li J,Qie P,Li Z,Xu Y,Tian Z

更新日期：2021-12-01 00:00:00

abstract：:Purpose: The aim was to describe patients' lived experience of warmth and coldness in connection with surgery. Methods: A reflective lifeworld research (RLR) approach founded on phenomenology and the methodological principles of openness, flexibility, and bridling were used. The data consisted of 16 in-depth interview...

authors： Gustafsson IL,Rask M,Schildmeijer K,Elmqvist C

更新日期：2021-12-01 00:00:00

abstract：:EsxA, secreted by the ESAT-6 secretion system 1 (ESX-1) secretion system, is considered the major Mycobacterium tuberculosis (Mtb) virulence determinant. However, the roles of the individual ESX-1 substrates, such as EspC, remain unclear due to their interdependency for secretion with EsxA. Here, we validated that Esp...

authors： Guo Q,Bi J,Wang H,Zhang X

更新日期：2021-12-01 00:00:00

abstract：:Oxythiamine (OT) and 3-deazathiamine (DAT) are the antimetabolites of thiamine. The aim of study was to compare the effects of OT and DAT pyrophosphates (-PP) on the kinetics of mammalian pyruvate dehydrogenase complex (PDHC) and the in vitro culture of HeLa cells. The kinetic study showed that 3-deazathiamine pyropho...

authors： Grabowska E,Czerniecka M,Czyżewska U,Zambrzycka A,Łotowski Z,Tylicki A

更新日期：2021-12-01 00:00:00

abstract：:The synthesis and carbonic anhydrase (CA; EC 4.2.1.1) activating effects of a series of oxime ether-based amino alcohols towards four human (h) CA isoforms expressed in human brain, hCA I, II, IV and VII, are described. Most investigated amino alcohol derivatives induced a consistent activation of the tested CAs, with...

authors： Nocentini A,Cuffaro D,Ciccone L,Orlandini E,Nencetti S,Nuti E,Rossello A,Supuran CT

更新日期：2021-12-01 00:00:00

abstract：:The COVID-19 outbreak has catastrophically affected both public health system and world economy. Swift diagnosis of the positive cases will help in providing proper medical attention to the infected individuals and will also aid in effective tracing of their contacts to break the chain of transmission. Blending Artifi...

authors： Rangarajan AK,Ramachandran HK

更新日期：2021-11-30 00:00:00

abstract：:Drugs such as immunosuppressants and glucocorticoids used for the treatment of inflammatory bowel disease (IBD) have certain troubling side effects. Polysaccharide-based nanocarriers with high safety and bioavailability are often used in the construction of colon-targeted drug nanodelivery systems (DNSs). It can help ...

authors： Cui M,Zhang M,Liu K

更新日期：2021-11-15 00:00:00

abstract：:The use of edible coating/film to improve fresh produce's quality and shelf life is an old but reliable and popular method of preservation. Recently, plant-derived mucilages have been extensively used to prepare edible packages (MEPs). This review focuses on recent studies that characterize mucilages from different pl...

authors： Olawuyi IF,Kim SR,Lee WY

更新日期：2021-11-15 00:00:00

abstract：:Biobased and biodegradable films were prepared by physically mixing 2,3-dialdehyde cellulose (DAC) with two other biopolymers, zein and gelatin, in three different proportions. The antimicrobial activities of the composite blends against Gram-positive and Gram-negative bacteria increase with the increase of DAC conten...

authors： Mayer S,Tallawi M,De Luca I,Calarco A,Reinhardt N,Gray LA,Drechsler K,Moeini A,Germann N

更新日期：2021-11-15 00:00:00

abstract：:In this study, we developed Lactobacillus rhamnosus GG (LGG)-encapsulating exfoliated bentonite/alginate nanocomposite hydrogels for protecting probiotics by delaying gastric fluid penetration into the nanocomposite and their on-demand release in the intestine. The pore size of the bentonite/alginate nanocomposite hyd...

authors： Kim J,Hlaing SP,Lee J,Saparbayeva A,Kim S,Hwang DS,Lee EH,Yoon IS,Yun H,Kim MS,Moon HR,Jung Y,Yoo JW

更新日期：2021-11-15 00:00:00

abstract：:Novel superhydrophobic sodium carboxymethyl cellulose (CMC) modified polyurethane (MPU) was developed as the membrane material for controlled-release fertilizer (CRF) by cross-linking polymerization of 4,4'-diphenylmethane diisocyanate (MDI) and CMC-based modified polyol (CMP) which was made by grafting CMC onto polye...

authors： Wang Y,Sun M,Qiao D,Li J,Wang Y,Liu W,Bunt C,Liu H,Liu J,Yang X

更新日期：2021-11-15 00:00:00

abstract：:Abundant and renewable cellulose is a potential candidate for petroleum-derived synthetic polymers. However, the efficient dissolution of this material is problematic because of the high cost, severe reaction condition (e.g., high temperature) and environmentally unfriendly (e.g., toxic reagents, and solvent recyclabi...

authors： Tong Z,Meng J,Liu S,Liu Y,Zeng S,Wang L,Xia Q,Yu H

更新日期：2021-11-15 00:00:00

abstract：RATIONALE:Nitroanilines can exist in several tautomeric forms: nitro-amino, nitro-imino, and aci-imino. The importance of evaluating minor tautomeric species comes from the fact that even less abundant tautomers have been proved to play important roles in reaction mechanisms. METHODS:Electron ionization mass spectra o...

authors： Colasurdo DD,Pila MN,Laurella SL,Allegretti PE,Ruiz DL

更新日期：2021-11-15 00:00:00

abstract：:Carbon quantum dots/polyaniline (CQDs/PANI) nanocomposite was successfully prepared by in-situ polymerization of aniline. CQDs were synthesized hydrothermally from gelatin with a diameter size of 4.2 nm and a 17% quantum yield. FTIR, UV-vis absorption, fluorescence spectrophotometer, XRD, TEM, XPS and lifetime decay w...

authors： Ahmed HM,Ghali M,Zahra W,Ayad MM

更新日期：2021-11-05 00:00:00

abstract：:Solvent effects usually have an essential effect on excited-state intramolecular proton transfer (ESIPT) processes and fluorescence mechanism. This contribution presents new insights into a newly synthesized compound, namely, 10-hydroxy-11H-benzo [b]fluoren-11-one (10-HHBF), and its analogue 1-hydroxy-11H-benzo [b]flu...

authors： Zhan H,Tang Z,Li Z,Chen X,Tian J,Fei X,Wang Y

更新日期：2021-11-05 00:00:00

abstract：:The purpose of this corrigendum to the published work by the author Liu et al. (2021) is to correct the wrong use of Figures during the proof. ...

authors： Liu T,Tian M,Wang J,Tian X,Liu J,Feng L,Ma X,Cui J

更新日期：2021-11-05 00:00:00

abstract：:We hereby review molecular dynamics simulations for anharmonic gas phase spectroscopy and provide some of our opinions of where the field is heading. With these new directions, the theoretical IR/Raman spectroscopy of large (bio)-molecular systems will be more easily achievable over longer time-scale MD trajectories f...

authors： Gaigeot MP

更新日期：2021-11-05 00:00:00

abstract：:This study evaluated the potential of Micro-Electro-Mechanical System (MEMS) and optical fiber Near-Infrared (NIR) spectrometers as a rapid method for monitoring total acids (TA) and total polyphenol content (TPC) in the fermentation process of mulberry vinegar. The NIR spectrometers Digital Light Processing (DLP) NIR...

authors： Sedjoah RA,Ma Y,Xiong M,Yan H

更新日期：2021-11-05 00:00:00

abstract：:The reaction system between the simplest Criegee intermediate, CH2OO, and the greenhouse gas CO2 has been investigated by Fourier transform microwave spectroscopy. The CH2OO-CO2 weakly bound complex was identified in the rotational spectrum, where inversion doublets due to the tunnelling motion between two equivalent ...

authors： Cabezas C,Daly AM,Endo Y

更新日期：2021-11-05 00:00:00

abstract：:The strength and geometry of adsorption of substituted phenylpyruvates on silver surface was studied by means of surface enhanced Raman spectroscopy (SERS) using silver sol. 2'-nitrophenylpyruvates were used as starting materials in a newly developed heterogeneous catalytic asymmetric cascade reaction to produce subst...

authors： Tálas E,Szőllősi G,Kristyán S,Németh C,Firkala T,Mink J,Mihály J

更新日期：2021-11-05 00:00:00

abstract：:Synthesis, spectral properties, and photodynamic activity of water-soluble amino acid fullerene C60 derivatives (AFD) and four original AFD-PPa dyads, obtained by covalent addition of dye pyropheophorbide (PPa) to AFD, were studied. In aqueous solution, these AFD-PPa dyads form nanoassociates as a result of self-assem...

authors： Belik AY,Rybkin AY,Goryachev NS,Sadkov AP,Filatova NV,Buyanovskaya AG,Talanova VN,Klemenkova ZS,Romanova VS,Koifman MO,Terentiev AA,Kotelnikov AI

更新日期：2021-11-05 00:00:00

abstract：BACKGROUND:Toxicology studies have identified pregnancy as a window of susceptibility for endocrine disrupting chemicals (EDCs) and cardiometabolic indices in women. No study in humans, however, has examined EDC mixtures and cardiometabolic indices during pregnancy. METHODS:We used the Health Outcomes and Measures of ...

authors： Vuong AM,Braun JM,Sjödin A,Calafat AM,Yolton K,Lanphear BP,Chen A

更新日期：2021-11-01 00:00:00

abstract：:Native mass spectrometry analysis of membrane proteins has yielded many useful insights in recent years with respect to membrane protein-lipid interactions, including identifying specific interactions and even measuring binding affinities based on observed abundances of lipid-bound ions after collision-induced dissoci...

authors： Donor MT,Wilson JW,Shepherd SO,Prell JS

更新日期：2021-11-01 00:00:00

abstract：:Aluminum-coated polypropylene films are commonly used in food packaging because aluminum is a great gas barrier. However, recycling these films is not economically feasible. In addition, their end-of-life incineration generates harmful alumina-based particulate matter. In this study, coating layers with excellent gas-...

authors： Nguyen HL,Tran TH,Hao LT,Jeon H,Koo JM,Shin G,Hwang DS,Hwang SY,Park J,Oh DX

更新日期：2021-11-01 00:00:00